UPDATE: The revised Sunday numbers are starting to favor The Hangover.  That’s good news for anyone trying to get an R-rated comedy made.

Up killed it again this week, narrowly outearning The Hangover ($44.2 mil to $43.3) and becoming the first two-week number one of 2009 (though these are still “estimated” numbers – The Hangover may still be number one when “actual” numbers are released tomorrow).   Up fell just 35% in its second week.  Oh, and expect to see a lot more Zach Galifianakis.

Land of the Lost earned almost $20 mil for third place, though people are already calling it the “first bomb of summer.”  Elsewhere, Sam Mendes/Dave Eggers/Vendela Vida’s Away We Go made $35,815 per theater in limited release, probably all from semi-employed liberal arts majors.

And finally, Angels & Demons added $6.5 mil domestically, but the big story is that it surpassed $409 million worldwide, the highest grossing film of 2009.  So next time some foreigner tries to give you crap about Americans being dumb, poke your finger in his chest and drunkenly slur something about how it’s his fault Tom Hanks turned into Nic Cage.  Full top 10 after the jump.

Title (studio) – weekend (per screen) – cumulative  [in millions]

1 – Up (Disney) – $44.24 ($11,588) – $137.32
2 – The Hangover (Warner Bros.) – $43.28 ($13,328) – $43,28
3 – Land of the Lost (Universal) – $19.53 ($5,545) – $19.53
4 – Night at the Museum: Battle of the Smithsonian (Fox) – $14.65 ($6,218) – $127.34
5 – Star Trek (Paramount) – $8.40 ($2,623) – $222.80
6 – Terminator Salvation (Warner Bros.) – $8.18 ($2,474) – $105.50
7 – Drag Me to Hell (Universal) – $7.34 ($2,925) – $28.53
8 – Angels & Demons (Sony) – $6.50 ($2,222) – $116.13
9 – My Life in Ruins (Fox Searchlight) – $3.23 ($2,771) – $3.23
10 – Dance Flick (Paramount) – $2.00 ($1,172) – $22.67

[via boxofficemojo, CNN, Cinematical]